Loading...
 
Toggle Health Problems and D

Low Vitamin D associated 1.8X increased risk of COVID-19 death in hosptial – meta-analysis Nov 4, 2020

Low serum vitamin D level and COVID-19 infection and outcomes, a multivariate meta-analysis

Jie Chen, Lixia Xie, Ping Yuan, Jianyong Ma, Peng Yu, Chunhua Zheng, Xiao Liu
Preprint Oct 27 doi: https://doi.org/10.1101/2020.10.24.20218974

Objective: This study aimed to determine whether serum vitamin D is independently associated with COVID-19 infection and outcomes in patients with COVID-19.

Methods: We identified relevant studies by searching the PubMed, Embase, and medRxiv databases from December 2019 to October 1, 2020. Odds ratios (ORs) were pooled using random-effects models. Only reports with multivariate adjusted results were included to avoid the impact of potential confounding factors.

Results: A total of six studies with 377,265 patients were identified. Overall, in the categorical analysis, a low serum vitamin D level was associated with an increased risk of COVID-19

  • infection (OR: 1.47, 95% CI: 1.09- 1.97, I2=81%),
  • hospitalization (OR: 1.83, 95% CI: 1.22-2.74, I2=0%),

but not in-hospital death (OR: 2.73, 95% CI: 0.27-27.61). Notably, when vitamin D level was analyzed as a continuous variable, each 5 ng/ml increase in vitamin D level was not associated with any increased risk of COVID-19 infection (OR: 1.04, 95% CI: 0.96-1.12, I2=74%) or in-hospital death (OR: 1.02, 95% CI: 0.93-1.12).

Conclusions: Low serum vitamin D is associated with an increased risk of COVID-19 infection and hospitalization. In-hospital death showed a tendency to be increased in COVID-19 patients with low vitamin D levels. The ongoing clinical trials for evaluation of vitamin D supplementation will be key to the validation of this adjunctive treatment for COVID-19 patients.

 Download the final Nov 4 peer-reviewed version from sci-hub Vitamin D Life
     Download the previous Oct 27 pre-print version from Vitamin D Life


See also: COVID-19 1.7X more likely to be severe if low Vitamin D - meta-analysis Oct 2020

COVID-19 treated by Vitamin D - studies, reports, videos

As of Dec 1: 36 trials, 4 trial results, 3 meta-analyses, 32 observations, 15 recommendations, 35 associations, 80 speculations, 29 videos

Top Vitamin D and COVID-19 recent updates

Many clinical trials are underway which are testing Vitamin D to fight COVID-19

COVID-19 RCTs

Title change made Nov 2020 caused the visitor count to reset.
There have actually been 512 visitors to this page since it was originally made


Attached files

ID Name Comment Uploaded Size Downloads
14593 D COVID Meta Sci-hub.pdf PDF 2020 admin 20 Nov, 2020 13:49 1.77 Mb 10
14530 Meta-Analysis COVID-19.pdf PDF 2020 admin 05 Nov, 2020 10:24 1.87 Mb 8
14505 Low serum vitamin D level and COVID-19 infection and outcomes, a multivariate meta-analysis Oct 27 PP.pdf PDF 2020 admin 31 Oct, 2020 00:05 1.48 Mb 27
See any problem with this page? Report it (FINALLY WORKS)